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The benefit is most pronounced for people who are still actively struggling with GI side effects or who are about to escalate to a higher dose

Phase 3 data will be pivotal

GIP is the main incretin hormone in healthy people, causative of most the incretin effects, but the insulin response after GIP secretion in type 2 diabetes mellitus (T2DM) is strongly reduced

Most experienced researchers recommend dropping back to a lower escalation dose and working up gradually, even with prior GLP-1 agonist experience

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